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  • Eddie Norton posted an update 5 months, 1 week ago

    One of the most important confounding factors in this context is cognitive function due to the close association with cognitive function and IADL29. In order to reduce this effect we adjusted also for cognitive function (measured by MMSE). In this adjustment we used the cut-point 26, which was based on the mean value of MMSE among our study subjects. The MMSE value 26 has been used also as a discriminatory value when screening cognitive deficiencies30. General dental practice for elderly people is predominantly focused on somatic diseases and medication. However, our results highlight the importance for dentists to identify patients who may be unable to perform the instrumental activities of daily living and, therefore, may require assistance to maintain adequate oral self-care. Our results suggest that elderly people, especially those Bcl-2 cancer with impaired functional ability, may have difficulties in plaque removal. To promote oral cleanliness powered toothbrushes could benefit elderly people with and without functional impairment because it has been found that powered toothbrushes reduce plaque and gingivitis significantly better than manual toothbrushes31�C33. In addition, patients with xerostomia problems, which are common among elderly people, may benefit from using powered toothbrushes34. In conclusion, this study suggests that home-dwelling elderly people who are unable to perform the activities of daily living are at risk for inadequate oral self-care. IADL scores, but not the handgrip strength, appear to be an important determinant of oral self-care among the home-dwelling elderly. The GeMS-study was financially supported by the Social Insurance Institute of Finland and the city of Kuopio. Kaija Komulainen wishes to thank for The Finnish Dental Society for financial support, Piia Lavikainen for statistical guidance and J. Simon Bell for revision of the English text. “”To date, there have been very little data on the cytotoxic responses of different cell lines to denture adhesives. To determine the cytotoxicity of three denture adhesives on primary human oral keratinocytes (HOKs), fibroblasts (HOFs) and permanent mouse fibroblasts cell lines (L929). Three commercial denture adhesives (two creams and one powder) were prepared for indirect contact using the agar diffusion test, as well as extracts in MTT assay. The results of the MTT assay were statistically analysed by one-way anova and Tukey’s test (p?<?0.05). All of the tested denture adhesives showed mild to moderate cytotoxicity to primary HOKs (p??0.05) in both assays. For primary HOFs cultures, slight cytotoxicity was observed for one of the products from the agar diffusion test and undiluted eluates of all tested adhesives with MTT assay (p?<?0.01). Denture adhesives are toxic to the primary HOKs and HOFs cultures, whereas non-toxic to L929 cells.