• Scott MacDonald posted an update 1 week, 2 days ago

    Und group has recommended that the previously “Urobasal” subtype defined by them modify name to “Urotheliallike” abbreviated as Uro, and that “UroA” and “UroB” be retained as for the previously described subtypes which, in complete, really should be known as “Urotheliallike A” and “Urotheliallike B” subgroups (hence, for the sake of clarity, it is not advisable the usage of the term “urobasal” for these subgroups). The group agreed to reconvene within the future to update the consensus evidence and to create strategies for future collaboration.Meeting attendees: M. Aine, Y. Allory, E. Carrillode Santa Pau, D. G. Pisano, K. Chan, L. Dyrskjot, A. Hartmann, K. Hoadley, M. Hglund, W. Kim, S. P. o Lerner, N. Malats, M. Marqus, D. J. McConkey, B. e Mellado, T. C. McKee, F. Radvanyi, F. X. Genuine, A. de Reyni` s, G. Sjdahl. e o CONFLICT OF INTEREST The authors have no conflict of interest to disclose. ACKNOWLEDGMENTS We would prefer to thank all the meeting attendants for their participation and discussion, and N. Malats and E. Carrillode Santa Pau for contributions to a earlier version in the paper. This manuscript as well as the Bladder Cancer Classification Consensus Meeting that led to its improvement have been supported by a grant from Astellas Pharma Europe Ltd provided to Title Loaded From File Universitat Pompeu Fabra, UPF. Astellas Pharma Europe Ltd holds no duty for the origination, improvement and content material of either the manuscript or the meeting, such as the agenda, selection of participants, manuscript author, editorial control or distribution.S.P. Lerner et al.A Consensus Bladder Cancer Molecular Taxonomy subtypes and an association in between gene copy number and methylation status. Epigenetics ;:. Aine M, Sjdahl G, Eriksson P, Veerla S, Lindgren D, Ringnr o e M, Hglund M. Integrative epigenomic analysis of differeno tial DNA methylation in urothelial carcinoma. Genome Med ;:. Eriksson P, Aine M, Veerla V, Liedberg F, Sjdahl G, Hglund o o M. Molecular subtypes of urothelial carcinoma are defined by certain gene regulatory systems. BMC Med Genomics ;:. doi: .s Aine M, Eriksson P, Liedber F, Sjdahl G, Hglund M. o o Biological determinants of bladder cancer gene expression subtypes. Sci Rep ;:. Damrauer JS, Hoadley KA, Chism DD, Fan C, Tiganelli CJ, Wobker SE, Yeh JJ, Milowsky MI, Iyer G, Parker JS, Kim WY. Intrinsic subtypes of highgrade bladder cancer reflect the hallmarks of breast cancer biology. Proc Natl Acad Sci USA ;:. Chan KS, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, Gill H, Presti J Jr, Chang HY, van de Rijn M, Shortliffe L, Weissman IL. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumorinitiating cells. Proc Natl Acad Sci USA ;:. Kurtova AV, Xiao J, Mo Q, Pazhanisamy S, Krasnow R, Lerner SP, Chen F, Roh TT, Lay E, Ho PL, Chan KS. Blocking PGEinduced tumour repopulation abrogates bladder cancer chemoresistance. Nature ;:. Rebouissou S, BernardPierrot I, de Reynies A, Lepage ML, Krucker C, Chapeaublanc E, Herault A, Kamoun A, Caillault A, Letouze E, Elarouci N, Neuzillet Y, Denoux Y, Molinie V, Vordos D, Laplanche A, MaillP, Soyeux P, Ofualuka e K, Reyal F, Biton A, Sibony M, Paoletti X, Southgate J, Benhamou S, Lebret T, Allory Y, Radvanyi F. EGFR as a prospective therapeutic target for a subset of muscleinvasive bladder cancers presenting a basallike phenotype. Sci Transl Med ;:ra.